Scientific Advisory Board
Friedhelm Hildebrandt, M.D.
Professor of Pediatrics and of Human Genetics
Frederick G.L. Huetwell Professor for the Cure and Prevention of Birth Defects
University of Michigan Department of Pediatrics
1150 West Medical Center Drive
8220C MSRB III
Ann Arbor, MI 48109
Business: (734) 615-7285
Business Fax: (734) 615-1386
Email: fhilde@umich.edu
Dr. Friedhelm Hildebrandt is a Professor of Pediatrics and Human Genetics at the University of Michigan. He also holds of the honor of being a Frederick G. L. Huetwell Professor for the Cure and Prevention of Birth Defects. Dr. Hildebrandt is a recipient of the Franz Volhard Award of the German Society of Nephrology, the E. Mead Johnson Award for Pediatric Research from the Society for Pediatric Research, and a Doris Duke Distinguished Clinical Scientist Award. Most recently, he was elected member of the German Academy of Sciences Leopoldina.
Dr. Hildebrandt received his M.D. from Heidelberg University in Germany. Dr. Hildebrandt’s clinical interests include hereditary renal disease. His laboratory focuses on the positional cloning of genes that cause kidney diseases such as cystic kidney diseases, nephronophthisis, urinary tract malformations, nephrotic syndrome, and Bartter syndrome. His lab also studies the molecular genetics and functional aspects of developmental defects of the kidney, eye and auditory system.
Dr. Hildebrandt is credited with several publications and awards pertaining to chronic kidney diseases. He has worked with Dr. Roger Wiggins, another NephCure board member, on projects concerning Nephrotic Syndrome.
Selected Publications:
1Attanasio M, 1Uhlenhaut HN, Sousa V, Dr. O'Toole JF, Otto E, Anlag K, Klugmann C, Treier AC, Sayer JA, Helou H, Seelow D, Nuernberg G, Becker C, Chudley A, Nuernberg P, 2Hildebrandt F, 2Treier M. Loss of GLIS2, a Kruppel-like zinc finger transcription factor, causes nephronophthisis in humans and mice by increased apoptosis and fibrosis. Nature Genet 39:1018-24, 2007
Hinkes B, Wiggins RC, Gbadegesin R, Vlangos C, Seelow D, Nurnberg G, Garg P, Verma R, Chaib H, Hoskins BE, Ashraf S, Dietrich A, Becker C, hennies HC, Wharram B, Kennedy MA, Schachter A, Drummond I, Kerjaschki D, Waldherr R, Kelley GC, Ozaltin F, Bakkaloglu A, Petry M, Kispert A, Cleper R, Basel L, Katan M, Liu J, Attanasio M, O'Toole JF, Hasselbacher K, Mucha B, Otto EA, Goyal M, Leroux MR, Gudermann T, Smrcka A, Holzman LB, Nurnberg P, & Hildebrandt F. Positional cloning of PLCE1 mutations as the first cause of nephrotic syndrome with partial response to therapy. Nature Genet 38:1397-1405, 2006 (editorial p. 1360-63)
Sayer JA, Otto EA, O'Toole JF, Nurnberg G, Kennedy MA, Becker C, Hennies HC, Helou J, Attanasio M, Fausett BV, Utsch B, Khanna H, Liu Y, Drummond I, Kawakami I, Kusakabe T, Tsuda M, Ma L, Lee H, Larson RG, Allen SJ, Wilkinson CJ, Nigg EA, Shou C, Lillo C, Williams DS, Hoppe B, Kemper MJ, Neuhaus T, Parisi MA, Glass IA, Petry M, Kispert A, Gloy J, Ganner A, Walz G, Zhu X, Goldman D, Nurnberg P, Swaroop A, Leroux MR, & Hildebrandt F. A novel centrosomal protein, nephrocystin-6, is mutated in Joubert syndrome and activates transcription factor ATF4. Nature Genet 38:674-681, 2006